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When the receptor is “unlocked” by its designated molecule, chemical reactions occur. Neurons and neuronal networks, much like telephone wires, carry messages across the body to different locations, initiating the production of messenger molecules which bind to specific receptors in a lock-and-key fashion. Running triggers messages sent by brain neurons to tell the body something needs to be done to control the stressful stimuli. When the body is placed under stress from exercise, it has internal mechanisms to cope with and prevent damage. Each runner experiences his or her own “runner’s high,” and scientists must rely on correlations between subjective descriptions and changes in physiological activity. An added challenge of investigating the runner’s high is that the feeling is subjective. However, there’s a debate in the sports-science community as to which system is the primary cause. Runners often experience these feelings during and after long and intense training sessions or races.īut what causes this sensation? While there are many biochemical systems in our body that regulate mood, the opioid and endocannabinoid systems are believed to be the main players in the runner’s high experience. The term “runner’s high” is a well-documented, subjective sensation that’s typically described as enhanced energy, harmony, and reduced pain perception. And yet, it is the “high” we get after a great workout that keeps us craving another run. The last time you said, “I love running,” how many bewildered looks did you get? For those who have never experienced that post-run euphoria, it may be hard to comprehend why we put in the miles day after day.